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Without sufficient subchondral load support, subsequent cartilage treatment approaches may be predisposed to failure, and thus, the entire osteochondral unit must be considered in this cohort of patients

Selenium and brain function: a poorly recognized liaison

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Copper levels in the brain of cuprizone-treated mice are altered [28, 90, 91], though the extent of this change is unclear, as studies on copper levels in the brains of cuprizone-treated mice are contradictory