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In some embodiments, mucoadhesive characteristics are also imparted to otic formulations disclosed herein, by incorporation of mucoadhesive carbomers, such as Carbopol 934P, to the composition (Majithiya et al., AAPS PharmSciTech (2006), 7(3), p

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In areas of increased hypoxia, HIF1 and expression of the lactate transporter MCT4 (monocarboxylate transporter-4) are induced
