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However, this is where many people run into a significant hurdle
Berhane K, Widersten M, Engstrom A, Kozarich JW, Mannervik B
PLoS ONE 5 , e10399 (2010)
The involvement of efflux proteins is known to be one of the major factors influencing the therapeutic efficacy of drugs, and this is no different in the case of PROTACs
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