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Free Radicals in Biology and Medicine (Oxford University Press, 2015)

protection against the carcinogenesis process[18]

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In conclusion, our study provides significant preclinical evidence that targeting the CDK4/6-DUB3 axis is an effective therapeutic strategy to destabilize YAP1 and suppress HCC progression

These include the rule of exponents method, which uses maximum lifespan potential and brain weight to correct the exponent,15 liver blood flow,20 and correction for in vitro metabolic clearance.21 The method of choice will depend on the PK characteristics of the drug candidate and the data available for scaling