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Sustaining the engine: mitochondrial quality control and transport networks As the central engine of cellular bioenergetics and intermediary metabolism, mitochondrial functional integrity is critical for sustaining high metabolic flux, anabolic potential, and therapeutic responsiveness in CRC [18]
It is notable that treatments that favor ER oxidation such as diamide or overexpression of constitutively active ERO1 elicit only modest ER stress (Hansen et al., 2012) (data not shown)
Int J Radiat Oncol Biol Phys 96(2S):S223, 2016
