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The nominations span three distinct clinical applicationsa breadth that reflects the compounds unclear mechanism of action more than its clinical validation
Upon activation, AMPK can phosphorylate key proteins of multiple signaling pathways mentioned above to exert regulatory effects
AMPK is an energy-sensing kinase that responds to the rise in AMP:ATP and ADP:ATP ratios and DNA damage [28]
However, despite high prevalence of systemic hypertension in patients with HFpEF, intensive blood pressure control only reduces HFpEF events but does not alter disease outcomes (Upadhya et al., 2021)
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