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chinese deficiency gene for glutathione liver disease peroxidase 1 attenuates concanavalin A-induced hepatic injury by modulation of T-cell activation Frontiers | Mechanisms of ferroptosis
Description
LOUZIR, B., M'SADEK, F., BATTIKH, R., BEN ABDELHAFIDH, N., HARZALLAH, O., BEKIR, S., & OTHMANI, S

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Thus, similar to peroxide-mediated inactivation of GPx-1, the in vivo role of RNS-mediated pathways of GPx-1 inactivation may depend on the overall intracellular redox environment, including concentrations of GSH, the ratio of GSH/GSSG, and the amount of RNS produced

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Precursor recycling (e.g., NR, NMN) also wanes due to reduced enzyme efficiency in salvage pathways
