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That said, even with triple the vitamin B12 intake, pregnant mothers serum vitamin B12 dipped into the low-to-mid range of normal in this study

Alcohol use disorder: Alcoholism can interfere with vitamin B12 metabolism
In keeping with those findings, a post-hoc analysis of a randomized controlled 4.3-year trial conducted in insulin-treated T2D patients reported that addition of metformin not only reduced serum vitamin B12 levels, but also gradually increased serum MMA levels[49]
All groups exhibited a significant reduction in wound area after 3 days of treatment compared to the NC group

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