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NAD+ precursor supplementation using NMN, NR, or NAD+ directly increases the input to the NAD+ salvage pathway

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Animal model studies have preliminarily revealed that Clostridium colonization can curtail the overgrowth of pro-inflammatory microbiota, restore the intestinal mucosal barrier, and limit systemic translocation of bacterial LPS, ultimately reestablishing gut microbial homeostasis (206, 207)

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