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2.3 Lung fibroblasts and smooth muscle cells Small airway illness results from ongoing airway remodeling, marked by chronic mucus hypersecretion and fibroblast activation, leading to increased synthesis of extracellular matrix (ECM) proteins and subsequent hardening of the airway wall [10]

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Diabetes Care 33 , 15491554 (2010)

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Pro-oxidant strategies Radical-focused strategies Radical-focused pro-oxidant strategies represent a distinct therapeutic paradigm that deliberately exploits the fundamental chemical properties of ROS, their extremely high reactivity, short diffusion lengths, and capacity for localized, diffusion-limited, and often irreversible chemical reactions, to induce precise and potent cytotoxicity at the nanoscale to submicrometer scale (Fig