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10.1016/j.mtbio.2022.100484 [DOI] [PMC free article] [PubMed] [Google Scholar] 219.Z

Abstract The majority of anticancer agents have a reduced or even complete loss of a therapeutic effect within hypoxic tumors

Glucose-6-phosphate dehydrogenase (G6PD) in the pentose phosphate pathway is the dominant enzyme that produces the required amount of NADPH during the conversion of glucose-6-phosphate to D-glucono-1,5-lactone-6-phosphate [63]
[DOI] [PubMed] [Google Scholar] 83.Dringen R., Gutterer J.M., Gros C., Hirrlinger J

Concentrations decline with age
