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Clementino AR, et al

On the other hand, TB 500, or Thymosin Beta-4, offers potent anti-inflammatory and regenerative benefits

The lack of effect on dopamine transmission with other types of antidepressants may be a possible cause of residual symptoms such as impaired motivation, concentration, and pleasure, even in patients who initially respond to other antidepressants

Concurrently, these individuals display depletion of immunomodulatory taxa like Bifidobacterium and Lactobacillus , alongside pathobiont enrichment such as Escherichia colia microbial signature that may perpetuate inflammatory cascades (Heinrich et al., 2023