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It should be noted that an increase in hepatic MnSOD, CAT, and GSH observed in animals from S + M group (Table 3) was not linked to the Nrf2 expression level, which remained unchanged in comparison to the sham-operated controls (Fig

3), gene expression and metabolomics pathway analyses also suggested extensive changes in pathways involved in SKM fat oxidation (Fig

There is marked variability in the clinical course, with some patients requiring wheelchair assistance in childhood and others walking in adulthood