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However, PHGDH and SHMTs are also important for immune cells metabolism and function, at least against fungi and viral infections [123, 124], respectively, and the specific delivery of inhibitors to tumor cells might be the best therapeutic alternative in this case, not affecting immune cells-mediated antitumor immunity

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25 MRI/QSM Data Acquisition All proton ( 1 H) MRI/MRS data on PD and HC were acquired using a Philips Achieva 3T scanner at NBRC, India