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[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Diaz GJ, Vargas ML, Cortes A

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Figure 3 4.2 Necroptosis promotes antigen cross-presentation and durable immunity Restoration of necroptotic signaling in melanoma, either through epigenetic modifier inhibitors to reverse RIPK3/MLKL silencing or direct small-molecule activation of the RIPK1/RIPK3/MLKL axis, enhances tumor cell immunogenicity by amplifying DAMP release and antigen cross-presentation, a phenomenon that has been validated in both in vitro melanoma cell models and in vivo syngeneic melanoma mouse models (106)

Understanding which combinations make mechanistic sense and which should be avoided is important for safe and effective protocols

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