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297 , E289E296 (2009)

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Therefore, to enhance mitochondrial complex I activity, NAD + levels were boosted in fly models of PD with NAM, leading to reduced oxidative stress, including lower ROS levels and DNA damage, as well as improved climbing ability 281

additionally, more research is required to investigate differences between NAD + modulators within different tissues, different models or pathologies, administration or exercise regimens, and how to successfully translate these findings to humans, while several clinical trials have already been conducted