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While the Fe-S cluster is critical for activity, its role for the reaction mechanism remains unclear ( in vitro using glutathione disulfide (GSSG) or in vivo in response to ozone and paraquat, and inactivated upon reduction (Kopriva and Koprivova, 2004)

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In addition, caspase 8 can cleave Bid (Bcl-2 interacting domain), a pro-apoptotic factor that, once cleaved, activates the intrinsic pathway of apoptosis by interaction with pro-apoptotic factors Bak and Bax

However, the hepatoprotective activity of melatonin in chronic liver injuries is more favorable of acute liver injuries [64]