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Psoriasis can be both physically and psychologically debilitating

Guo H, Sun J, Li D, et al

It is suspected that the gut-brain axis is a network of complex interactions between the nervous and GI systems with significant contributions from intestinal microbiota

Glucose is the principal precursor for GABA production via its conversion to -ketoglutarate in the TCA cycle

The ratio of phoshos-JNK1/2 to total-JNK1/2 as well as the ratio of phospho-p38 to total p38 (which are indicative of JNK1/2 and p38 activation) were estimated and expressed as % control, by normalizing with the value of the non-LPS group (JNK1/2: left panel, p38: right