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The increase in sphingomyelins can interfere with signaling pathways, including phosphatidylinositol 3-kinase (PI3K)/AKT and MAPK, inhibiting cancer cell proliferation and growth (222)

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Proc Natl Acad Sci U S A 85(15):54195423 Suh PG et al (1988) Cloning and sequence of multiple forms of phospholipase C

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