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This phosphorylates and inhibits GFPT1, thereby weakening YAP protein stability and the transcription of its downstream target gene FTH1, ultimately promoting ferritinophagy, lipid peroxidation, and enhanced ferroptosis susceptibility (50)

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Among the NK cells subset, CD56 dim PC-phospholipase C bright cells are associated with cytotoxic function, whereas CD56 bright PC-phospholipase C low/- cells exhibit immunoregulatory properties (133) ( Figure 3 )

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Intestinal flora can synthesize bile acid (BA) and short-chain fatty acid (SCFA) to regulate MASLD