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2 chlorodeoxyadenosine (2-CdA) and cytarabine (Ara-C) combination is effective and safe in idiopathic hypereosinophilic syndrome (HES)

This enzyme complex is composed of the E1 component protein encoded by the DHTKD1 (dehydrogenase E1 and transketolase domain containing 1) gene and shares the E2 (dihydrolipoamide S-succinyltransferase: DLST) and E3 (dihydrolipoamide dehydrogenase: DLD) components of the 2-oxoglutarate complex of the TCA cycle (commonly called -ketoglutarate dehydrogenase)

Curr Opin Food Sci (2022) 47:100882

While mouse models have been used to identify altered signaling pathways conserved in MS lesions, a direct comparison of mouse toxicity-induced demyelination models to human MS lesion transcriptomics across multiple cell types has not been performed 9,16