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The effectiveness of a low-histamine diet has been demonstrated in clinical studies, which report favorable results in terms of improvement or total remission of symptoms frequently associated with histamine intolerance and DAO deficiency (Table 4)

Effects of Spirulina platensis on pain and inflammation in long Evans rats

Moreover, silencing TFRC, which restricts the intake of iron into cells, can also suppress ferroptosis [129]

This creates a broad prohibition that captures emerging peptides even before specific detection methods are developed

The findings underscore the importance of focusing on metabolic reprogramming to develop safer and more effective therapeutic approaches