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What the Research Says In a 2006 double-blind clinical trial, participants with knee osteoarthritis who took 6g of MSM daily for 12 weeks experienced statistically significant reductions in pain and improved daily functioning compared to placebo (Kim et al., 2006)

However, the emergence of drug-resistant strains in some individuals remains a major challenge, reducing overall cART efficacy and warranting the need for novel therapeutic strategies

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By modulating mitochondrial oxidative phosphorylation via the AKT/GSK3/-catenin signaling cascade, TBP enhances the growth, migration, adhesion, and osteogenic differentiation of MC-3 T3-E1 cells