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In the murine collagen-induced arthritis model, in vivo intraperitoneal methotrexate treatment reduced TNF serum levels and diminished TNF production by splenic T cells and macrophages [96]

Psychiatry 22 (5), 387398

Ann Neurol 1994

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Initially described as a pro-atherogenic molecule due to its proliferative role in VSMC, it was further demonstrated that the effect of IGF-I on VSMC was to compensate for local apoptosis, and that, overall, IGF-I is not pro-atherogenic in native arteries but anti-atherogenic[320], mainly through enhanced nitric oxide production[308]