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Long-term PPI use may also promote bile duct epithelial proliferation and bile duct epithelial micropapillary growth, resulting in focal bile duct stenosis and obstruction, which may also be associated with gallstone formation (Yang et al., 2020)

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BPC-157 enhances growth hormone receptor expression, modulates VEGF and FGF signaling to promote angiogenesis and tissue repair , reduces pro-inflammatory cytokines TNF-alpha, IL-6, and IFN-gamma, and interacts with the nitric oxide system to provide endothelial protection