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Additionally, IGF-1 administration has been associated with increased tubular phosphate reabsorption.57,58 In the same way, other clinical studies have reported beneficial effects of recombinant IGF-1 on GFR in ESRD patients scheduled to begin renal replacement therapy or patients undergoing peritoneal dialysis.59,60 In vitro studies have supported the renal protective effects of IGF-1

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In contrast, mixing E2 immunogens from different strains can increase NAb breadth 68 , while nanoparticle presentation can enhance potency 22,25,29