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In contrast, the AIM-HIGH (Atherothrombosis intervention in metabolic syndrome with low HDL/high triglycerides: impact on global health outcomes) trial, which examined the incremental effect of extended-release nicotinic acid (1.5-2 g/day) on 3,414 patients who had established CVD and atherogenic dyslipidemia and were treated with simvastatin (+/- ezetimibe), provided disappointing results

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Gently swirl the vial in a circular motion

Personalized management strategies in mast cell disorders: ECNM-AIM users guide for daily clinical practice
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Nickoloff, B