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J.SancakY.FominaY.MeiselJ
The extracellular domain (Kl1 and Kl2) of mKlotho can be shed constitutively by anchored proteases and yields sKlotho (Zhong et al., 2020)
So it is not just glutathione levels in the body that are important, it is the ratio of the active to the inactive
Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U (2008) TMEM16A confers receptor-activated calcium-dependent chloride conductance
But again, these are potentialnot provenbenefits
