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Description
Colchicine is not safe in patients with substantial kidney or liver disease and should not be used along with drugs such as ketoconazole (eg, Nozoral), fluconazole (Diflucan), clarithromycin (Biaxin, an antibiotic), cyclosporine (eg, Sandimmune, an immunosuppressant agent), or ritonavir (Norvir, an antiviral drug) due to the potential for drug-drug interactions
Therefore, pancreatitis can have serious consequences and can even be life-threatening
3 kW 4,5 kW
hence, it is more preferable than cyanocobalamin for the treatment of vitamin B12 deficiency (1,2,3,4)
Its mechanism is strictly enzymatic (NNMT inhibition)
