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SLC7A5 and SLC1A5 are positively (+) associated with the differentiation of Th17 cells, 58 the addition of excessive amounts of glutamine can rescue the defect of the SLC1A5 / T cells in differentiation into Th17 cells, 28 GLS promotes differentiation and immune function of Th17 cells, 16,59 and GLS inhibition may inhibit the activation of mTOR signalling and differentiation of T cells through suppressing the production of polyamines 60 or glutathione or downregulating Th17-promoting transcription factor, IL-2 release downstream of mTORC1 signal is reduced

An update of targeted therapeutic options for primary Sjgren syndrome: current status and future development

doi: 10.1002/jcp.26170

Malondialdehyde (MDA) is a byproduct of lipid peroxidation and serves as an important marker for oxidative stress in cells and tissues (Yagi, 1994)

1 Additionally, the surgical procedure itself may cause new trauma to the endometrium, inducing secondary inflammation and re-adhesion