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Previous pharmacokinetic studies have shown that the peak concentrations of substances like clomipramine nanoparticles [75], dantrolene [76] or donepezil liposomes [77] in the brains of rodents can be reached as early as 2030 min after intranasal application

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Colijn MA, Grossberg GT

Based on the well-known and efficient chelation of lead and cadmium by DOTA in trace concentrations and even complex media (complex formation constants, log() DOTA = 22.69 and 21.3, respectively, See Table S0) 31,32 , its closely related derivative, DOTAGA, was chosen for functionalization of the polymer

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