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SAM is a methyl donor to several different receptors and forms S -adenosylhomocysteine (SAH) as a by-product of this methyl reaction
doi: 10.3389/fonc.2020.00188 25 MoeiniPNiedwiedzka-RystwejP
And intranasal inoculation of two airway lactobacillus (potential producers of airway IAA) for 6 weeks can alter the lung microbiome in mice, restore IAA levels, and exert a protective effect in COPD mice (121)
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