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Particularly, alveolar macrophages (AM) interact with pulmonary surfactants in the innate immune responses

The gamma-glutamyl cycle does allow some tissues (particularly the liver, kidney, and lung epithelium) to utilize extracellular glutathione more directly via membrane transporters

CD47 blockade disrupts SIRP-CD47 signaling, preventing lysosomal degradation of phagocytosed mtDNA in DCs, thereby enhancing cGAS sensing (78)

Inhibition of these enzymes increases histone acetylation, thereby enhancing antioxidant system function and upregulating peroxisome proliferator-activated receptor (PPAR) activity [39, 69]

No significant differences were found between the three groups of patients, demonstrating the low importance of the oxidant/antioxidant system in the pathogenesis of the disease