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Insulin receptors are abundant in the brain, however, concentrated in some areas such as the substantia nigra and basal ganglia

a prospective randomized pilot study

Thus, the major source of the circulating 24S-OHC is the brain and therefore, plasma levels of 24S-OHC reflects the number of metabolically active neurons which in turn reflects the volume of the gray matter structures

doi: 10.3390/ijms22095010

Golizeh M, Lee K, Ilchenko S, Osme A, Bena J, Sadygov RG, et al
