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For these patients there is currently no established therapeutic approach, which allows a favourable outcome

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Estrogens, all in all, have been found to exhibit an inhibitory effect on excessive sebaceous gland activity in vivo.[53] In order to avoid the risk of endometrial hyperplasia, or even cancer, that can result from unopposed estrogen, it must be used in combination with a progestin

187 On the other hand, poor eating habits, digestive problems, and metabolic disorders can disrupt gut microbial balance and circadian synchrony, potentially triggering sleep disorders