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Although discovered over 150 years ago, the action of the kynurenine pathways intermediate metabolites, known as kynurenines, has until recently been relatively little studied (Schwarcz et al., 2012)

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Axons are injured by antigen-specific CD8 + T cells through a MHC class I-and granzyme B-dependent mechanism

45,46 TMAO is Related to Thrombosis and Embolism in AF Patients Several observational studies have confirmed the association between TMAO and cerebrovascular disease

The toxins trigger a complex cascade of host cellular responses to cause diarrhoea, inflammation and tissue necrosis the major symptoms of CDI