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Because cyanide is a component of cyanocobalamin, we calculated the maximum cyanide load from various B12 regimens in the Cyanide Load tab of B12 Doses and Absorption

Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed

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It also helps to correct severe deficiencies very quickly (if the deficiency is not based on genetic abnormalities which may require a specific form(s) of B12)