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This is normal and preferable to damaged product

however, ADP and AMP levels were downregulated, and adenine exhibited a significant decline of 12.6-fold (Figure 4G)
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doi: 10.1073/pnas.97.20.10723

The co-delivery of mPEG-PLA and resveratrol exhibited stable plasma stability, decreased liver metabolic rate, and effectively inhibited tumor growth
