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The proposed assay involves centrifugation steps for the separation of plasma and for preparation of sample blank, which is a disadvantage that stored blood samples (which are usually hemolyzed) cannot be analyzed

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48 For instance, the overexpression of v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2), which is common in breast and ovarian carcinomas, 189, 190 has been suggested to promote CDDP resistance not only by delivering robust pro-survival signals via the v-akt murine thymoma viral oncogene homolog 1 (AKT1) signaling axis, but also by finely regulating the transitory cell cycle arrest that is required for the repair of CDDP-induced DNA lesions

L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity

PMID 12432220