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Gene therapy in retinal diseases: a review

Active CLK-CYC heterodimers stimulate transcription of target genes including the negative clock components encoded by period ( per ) and timeless ( tim ), which repress CLK-CYC activity

Palinski W, Rosenfeld ME, Yla-Herttuala S, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL

This leads to skin that feels thicker and more resilient, rather than thinner and more sensitive
