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In the first case, the reversible inhibition by Sporidesmin was successful only in in vitro conditions with recombinant enzymes but did not present satisfactory activity in cellular models, due to the competition with glutathione under physiological conditions

Compared with curcumin, the synthesized dimethyl curcumin pyrazole derivatives with N-p-phenylcarboxyamide substitution have higher binding affinity for P-gp and can effectively reverse MDR of chronic myeloid leukaemia to DOX (77)

doi: 10.1089/gtmb.2017.0062

The splenocytes obtained were devoid of erythrocytes and were centrifuged and resuspended in complete media

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