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Description
A 2025 Phase 3 trial in people with obesity and knee osteoarthritis showed nearly 29% weight loss plus meaningful pain relief
Autophagic degradation of substrates such as ferritin and GPX4 can elevate intracellular iron and lipid peroxides, thereby eliciting ferroptosis and stimulating antitumor immunity in non-small cell LC (NSCLC) (13)
Biochemical and physiological mechanisms
Excessive ROS can damage the membrane structure and proteins of the endoplasmic reticulum, disrupting its redox balance and thereby interfering with the processes of protein folding and modification (Xie et al., 2024)
They have applications in ELISA and other plate-based assay techniques
