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3) Potential off-target effects: At high doses, they may disrupt normal lipid metabolism or mitochondrial function
PMID: 7 FerrazEBorgesMCTerra-FilhoJMartinezJAViannaEO
Consequently, episodes of tissue injury and incomplete healing of the intestinal epithelium are a prerequisite for immune reactivation and account for recurrent, chronically progressing phenotypes of IBD

The interactions between PD-L1 and PD-1 normally help prevent immune-mediated tissue damage upon activation
Modulation of the in vitro angiogenic potential of human mesenchymal stromal cells from different tissue sources
