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Principal feasibility and translation barriers Synthesizing evidence from completed trials, four major barriers prevent widespread clinical adoption of these advanced therapies

Mechanism of activation of protein kinase B by insulin and IGF-1

Nature 395:645648

Nuclear factor erythroid 2-related factor 2 plays a fundamental role in the response to oxidative stress and xenobiotic metabolism and detoxification, and the Nrf2 signaling pathway is intimately associated with development of atherosclerosis

Administering iodine containing contrast agents can have noxious effects on the microbiota by binding to the amino acids tyrosine and histidine on the bacterial membrane, as well as by oxidation of cytoplasmic and membrane components [4]