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Lomas AJ, Ryan CN, Sorushanova A, Shologu N, Sideri AI, Tsioli V, et al
B12 deficiency top causes Pernicious anemia autoimmune destruction of parietal cells / intrinsic factor (IF)
Therefore, impairment of the insulin signaling pathway (PI3K/Akt/mTOR pathway) leads to IR, which may induce the synthesis and deposition of advanced glycation end products (AGEs), ROS, and reactive nitrogen species
In vitro experiments revealed that low glucose conditions (05 mM) significantly amplified metformins cytotoxicity in breast (MCF7, MDAMB231, SKBR3) and ovarian (OVCAR3, PA-1) cancer cell lines
Its important to have a touchstone in some data
