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and our group reported that macrophage and VMSCs apoptosis is necessary to reduce macrophage burden and stabilize the atherosclerotic plaque within the developing lesion in Apo E / mice [67, 68]

Given its high potential for impacting AD-relevant pathologies with low risk for adverse events, additional studies of melatonin in the context of AD appear warranted

However, this effect was reproduced by a novel ER agonist (55)

Deficiency in this mineral in particular individuals has been linked to, e.g., atherosclerosis, dyslipidemia, carbohydrate disorders with type 2 diabetes, myocardial infarction, hypertension, kidney stones, premenstrual syndrome, pre-eclampsia and psychiatric disorders

doi: 10.1208/s12248-025-01018-9 179 ZhangSLiuJOuyangXLiuWWangYZhongJ