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This higher baseline is protective

9 nights later woke up with pain in left hand

Think of it like physical therapy: you see small improvements quickly, but major results take time

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A 2016 phase 1B clinical trial, investigating the efficacy of NSI-189 in a randomized, placebo-controlled study design, indicated significant effects of the drug as orally administered to individuals suffering from MDD either once, twice or three times per day