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Together with IL-12 and IL-18 or transforming tumor necrosis growth factor (TGF)-, IL-6, and IL-23, TNF- induces the differentiation of nave CD4+ T cells into pro-inflammatory T helper cells of type 1 (T H 1) and type 17 (T H 17), respectively [6,12,13]
4,5,6,7-tetrabromo-2-azabenzamidazole (TBB), which specifically inhibits casein kinase 2 (CK2), was selected and discovered to preferentially trigger apoptosis in Zmpste24 / cells
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