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In the few studies of SCD, VR was well tolerated and engaging, although further research is needed to assess its long-term impact on preventing cognitive decline

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or simply methylTHF) derivative as a result of the loss of functional methionine synthase

Innovative drug delivery systems such as lipid nanoparticles and BBBpenetrant vectors are enhancing the feasibility of glia-specific interventions [493, 494]

Large-animal model validation is absent across all 17 studies, with efficacy confined to rodent models