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In order to expand the toolbox of protocols for one-pot PROTAC synthesis using building blocks with different functional groups, Krumbs group published a new library of cereblon-based PROTACs targeting BRD4 protein via amide formation after a one-pot synthesis photoinduced C(sp 2 )C(sp 3 ) coupling (yields ranging from 7 to 93%)

Expert Rev Clin Pharmacol

Effects and therapeutic mechanisms of MSCs on liver fibrosis Various cell therapies can alleviate liver fibrosis through several common mechanisms, including improving liver regeneration and regulating the liver microenvironment

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10.1021/acsnano.8b06201 79 SiegelR